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Biological evaluation of DBT (in vitro studies) |
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| Findings |
Model |
Treatment |
Reference |
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| The 5:1 ratio DBT showed stronger effects in stimulating MG-63 cell proliferation and induced ALP activity to the highest level among all groups. |
Cultured human MG-63 osteosarcoma cells |
DBT of various ratios of RA and RAS, compared with β-estradiol and negative control |
Dong et al. [19] |
| The 5:1 ratio DBT showed the strongest effect in inducing the estrogen-driven promoter activity than RA, RAS alone or the extracts of other ratios. |
Cultured MCF-7 cells |
DBT of various ratios of RA and RAS, compared with β-estradiol and negative control |
Dong et al. [19] |
| The ratios 5:1 and 7:1 DBT showed higher levels of activity in preventing platelet aggregation. |
ADP induced-platelet aggregation in blood from adult New Zealand white rabbits |
DBT of various ratios of RA and RAS, compared with ticlopidine and negative control |
Dong et al. [19] |
| DBT induced cell proliferation, interleukin-2 secretion and the phosphorylation of extracellular signal-regulated kinase (ERK1/2) in cultured T-lymphocytes. The 5:1 ratio DBT showed the strongest immuno-modulatory effects. |
Cultured T-lymphocytes and macrophages |
DBT of various ratios of RA and RAS, compared with PHA, PMA, Zymosan A and negative control |
Gao et al. [23] |
Gao et al. Chinese Medicine 2007 2:12 doi:10.1186/1749-8546-2-12 |
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