|
Contents (μg/g, mean ± SD, n = 3) of markers in Gegen Tang granule from four manufacturers |
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| Manufacturers and Batch No. |
Puerarin |
Paeoniflorin |
Cinnamic acid |
Daidzain |
Glycyrrhizin |
Ephedrine |
Pseudoephedrine |
|
|
|
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| A* |
Batch No.1 |
374.3 ± 3.1 |
270.5 ± 0.6 |
70.4 ± 0.4 |
52.1 ± 0.4 |
411.4 ± 2.8 |
731.4 ± 2.3 |
242.8 ± 2.3 |
| Batch No.2 |
440.8 ± 1.5 |
342.1 ± 2.7 |
89.7 ± 0.5 |
59.8 ± 0.5 |
542.6 ± 2.6 |
938.5 ± 8.8 |
322.4 ± 3.1 |
|
| Batch No.3 |
738.7 ± 4.1 |
353.8 ± 3.1 |
100.2 ± 0.7 |
131.4 ± 0.9 |
1558.3 ± 12.6 |
1162.0 ± 8.1 |
318.6 ± 2.0 |
|
| Mean (± SD) |
517.9 ± 194.1 |
322.1 ± 45.1 |
86.8 ± 15.1 |
81.1 ± 43.7 |
837.4 ± 627.7 |
944.0 ± 215.4 |
294.6 ± 44.9 |
|
| B* |
Batch No.1 |
733.4 ± 5.8 |
423.1 ± 2.0 |
72.1 ± 3.8 |
63.2 ± 1.0 |
1584.3 ± 12.2 |
2121.0 ± 7.4 |
482.6 ± 4.2 |
| Batch No.2 |
2273.4 ± 21.4 |
1339.6 ± 4.2 |
183.4 ± 1.7 |
302.6 ± 0.7 |
3314.6 ± 14.6 |
2863.4 ± 21.8 |
891.4 ± 3.7 |
|
| Batch No.3 |
1708.6 ± 11.6 |
1030.7 ± 6.5 |
149.7 ± 0.9 |
228.7 ± 0.8 |
3276.5 ± 23.9 |
1822.6 ± 0.7 |
609.7 ± 3.1 |
|
| Mean (± SD) |
1571.8 ± 779.1 |
931.1 ± 466.3 |
135.1 ± 57.1 |
198.2 ± 122.6 |
2725.1 ± 988.2 |
2269.0 ± 536.0 |
661.2 ± 209.2 |
|
| C* |
Batch No.1 |
1202.8 ± 14.0 |
4587.7 ± 16.1 |
224.1 ± 0.57 |
138.3 ± 0.8 |
5917.4 ± 39.1 |
2886.8 ± 0.7 |
743.7 ± 0.8 |
| Batch No.2 |
1479.4 ± 11.5 |
1672.4 ± 10.4 |
149.6 ± 0.7 |
162.6 ± 0.1 |
1814.2 ± 5.4 |
2293.7 ± 0.2 |
639.6 ± 4.5 |
|
| Mean (± SD) |
1341.1 ± 19.6 |
3130.1 ± 2061.4 |
186.9 ± 52.7 |
151.5 ± 18.6 |
3865.8 ± 2901.4 |
2590.3 ± 419.4 |
691.7 ± 10.7 |
|
| D** |
Batch No.1 |
5913.6 ± 48.5 |
4899.4 ± 25.5 |
323.6 ± 1.9 |
324.1 ± 0.6 |
5087.1 ± 45.3 |
3740.4 ± 1.0 |
902.4 ± 8.1 |
| Batch No.2 |
3417.7 ± 18.5 |
4341.6 ± 24.7 |
238.9 ± 0.6 |
179.6 ± 0.3 |
4958.3 ± 15.4 |
3172.6 ± 0.4 |
1002.4 ± 6.1 |
|
| Batch No.3 |
3711.5 ± 18.6 |
4124.8 ± 32.5 |
271.4 ± 2.6 |
242.4 ± 0.9 |
4079.6 ± 11.8 |
4577.8 ± 0.8 |
1203.8 ± 6.3 |
|
| Batch No.4 |
3889.3 ± 19.4 |
3128.7 ± 21.0 |
287.6 ± 2.0 |
263.7 ± 0.8 |
4189.3 ± 20.5 |
4329.6 ± 0.4 |
969.7 ± 5.2 |
|
| Batch No.5 |
4193.2 ± 17.2 |
3623.3 ± 26.1 |
304.4 ± 2.7 |
269.9 ± 0.7 |
3958.7 ± 17.0 |
3820.3 ± 0.4 |
1134.3 ± 8.5 |
|
| Batch No.6 |
4362.7 ± 18.6 |
3411.7 ± 14.0 |
313.2 ± 2.3 |
324.1 ± 0.5 |
4672.7 ± 20.1 |
2617.8 ± 0.8 |
933.1 ± 4.9 |
|
| Batch No.7 |
4438.6 ± 31.1 |
3462.6 ± 7.6 |
327.8 ± 2.3 |
317.8 ± 0.6 |
4729.7 ± 8.5 |
2624.0 ± 0.8 |
959.7 ± 8.0 |
|
| Mean (± SD) |
4275.2 ± 809.1 |
3856.0 ± 623.4 |
295.3 ± 31.8 |
274.5 ± 53.2 |
4525.0 ± 447.1 |
35554.6 ± 779.1 |
1015.1 ± 111.5 |
|
|
Values are means ± SD of triplicate tests. Single factor ANOVA was performed on each component. Contents of each compound showed significant differences among the four manufacturers (P < 0.05). * Significant differences were observed in different sample batches (P < 0.05). ** No significant difference was observed in the contents of each component in seven batches of GT from manufacturer D (P > 0.05). | ||||||||
Song et al. Chinese Medicine 2007 2:7 doi:10.1186/1749-8546-2-7 |
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