|
Effects of five Chinese medicine decoctions on liver hydroxyproline (Hyp) content in DMN-induced liver fibrosis of rats |
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| Group |
Group size (n) |
Hyp content μg/g mean (SD) |
Fibrotic grade* |
95% CI of U** |
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|
|
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| 0 |
1 |
2 |
3 |
4 |
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|
|
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| Control |
10 |
179.36(9.90)▲▲ |
10 |
0 |
0 |
0 |
0 |
(-0.110 to 0.228)▲▲ |
| 2-week DMN |
6 |
289.06 (26.95)▲▲ |
0 |
0 |
4 |
2 |
0 |
(0.051 to 0.486)▲▲ |
| DMN + water |
12 |
641.71 (54.22)△△ |
0 |
0 |
0 |
3 |
9 |
(0.586 to 0.894)△△ |
| DMN + YCHT |
12 |
434.16 (25.39)▲ |
0 |
0 |
5 |
6 |
1 |
(0.226 to 0.548)▲ |
| DMN + XYXT |
12 |
586.91 (37.53) |
0 |
0 |
0 |
5 |
7 |
(0.522 to 0.829) |
| DMN + HQT |
12 |
559.04 (47.06) |
0 |
0 |
0 |
8 |
4 |
(0.580 to 0.734) |
| DMN + YGJ |
12 |
647.17 (64.73) |
0 |
0 |
1 |
6 |
5 |
(0.435 to 0.743) |
| DMN + XCHT |
10 |
636.35 (48.53) |
0 |
0 |
1 |
7 |
2 |
(0.333 to 0.671) |
|
*: grade 0: normal; grade 1: very slight; grade 2: slight; grade 3: moderate; grade 4: severe. Data are expressed as numbers of animals with each fibrotic grade. **: 95% confidence interval of the U values obtained from ridit analysis ▲P < 0.05 ▲▲P < 0.01 (vs DMN+ water) △P < 0.05 △△P < 0.01 (vs 2-week DMN) YCHT: Yinchenhao Tang XYXT: Xiayuxue Tang HQT:Huangqi Tang YGJ: Yiguang Jian XCHT: Xiaochaihu Tang Results are expressed as mean (SD). | ||||||||
Liu et al. Chinese Medicine 2008 3:1 doi:10.1186/1749-8546-3-1 |
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