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Anti-inflammatory effects of Radix Gentianae Macrophyllae (Qinjiao), Rhizoma Coptidis (Huanglian) and Citri Unshiu Pericarpium (Wenzhou migan) in animal models

Kyoung Soo Kim1 email, Hae In Rhee2 email, Eun Kyung Park1 email, Kiwon Jung2 email, Hyo Jin Jeon2 email, Ji-Hong Kim2 email, Hunseung Yoo2 email, Chang-Kyun Han3 email, Yong-Baik Cho4 email, Chun Jeih Ryu5 email, Hyung In Yang6 email and Myung Chul Yoo7 email

1East-West Bone and Joint Research Center, Kyung Hee University Neo Medical Hospital, 149 Sangil-dong, Gangdong-gu, Seoul 134-090, South Korea

2Life Science Research Center, SK Chemicals, 600 Jungja-1-dong, Changan-Ku, Suwon-Si, Kyoungki-Do 440-745, South Korea

3Central R&D, Ahngook Pharm., Iui-Dong Yeongtong-gu, Suwon-Si, Kyoungki-Do, South Korea

4Central Research Institute, Whan In Pharm., Co., Ltd. Iui-Dong, Yeongtong-gu, Suwon-Si, Kyoungki-Do, South Korea

5Department of Bioscience and Biotechnology, Sejong University, Seoul 143-747, South Korea

6Department of Internal Medicine, Kyung Hee University Neo Medical Hospital, 149 Sangil-dong, Gangdong-gu, Seoul 134-090, South Korea

7Department of Orthopedic Surgery, Kyung Hee University Neo Medical Hospital, 149 Sangil-dong, Gangdong-gu, Seoul 134-090, South Korea

author email corresponding author email

Chinese Medicine 2008, 3:10doi:10.1186/1749-8546-3-10

Published: 2 September 2008

Abstract

Background

KHU14, an ethanolic extract of Radix Gentianae Macrophyllae (Qinjiao), Rhizoma Coptidis (Huanglian) and Citri Unshiu Pericarpium (Wenzhou migan) was tested for its anti-inflammatory effects.

Methods

Three out of 20 herbs were found to have anti-inflammatory effects. The formulation of these herbs, i.e. KHU14 was tested for croton oil-induced ear edema, carrageenan-induced paw edema, acetic acid-induced capillary permeability, cotton pellet and delayed type hypersensitivity.

Results

KHU14 exhibited anti-inflammatory effects in animal models of acute and chronic inflammation. The anti-inflammatory activity of KHU14 observed was comparable to that of celecoxib. KHU14 inhibited the production of NO and PGE2 in LPS/IFN-gamma-stimulated peritoneal macrophages, and reduced edema and the amount of infiltrated cells in animal models.

Conclusion

KHU14 exhibited anti-inflammatory effects as demonstrated in typical immunological tests for anti-inflammation in vitro and in vivo.

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