Table 2 |
||||||
|
Bax, bcl-2 and caspase-3 expression (in IOD) in tumor tissues of LLC in mice |
||||||
|
Percentiles |
||||||
|
Group (n = 10) |
Dose (mg/kg) |
Mean |
SD |
25th |
50th (median) |
75th |
|
|
||||||
|
Bax |
||||||
|
Control |
- |
13633 |
2531 |
11244 |
13712 |
15634 |
|
Acetylshikonin |
2 × 6 |
48678 |
2534 |
46432 |
48519*** |
51406 |
|
1 × 6 |
28502 |
5064 |
23628 |
30232*** |
33082 |
|
|
0.5 × 6 |
21844 |
4882 |
16476 |
22988** |
26209 |
|
|
bcl-2 |
||||||
|
Control |
- |
19859 |
2822 |
17076 |
20065 |
22292 |
|
Acetylshikonin |
2 × 6 |
8126 |
1115 |
7267 |
7926*** |
8596 |
|
1 × 6 |
11171 |
1459 |
9916 |
10814*** |
12478 |
|
|
0.5 × 6 |
15652 |
1724 |
14447 |
15234** |
16742 |
|
|
Bax/bcl-2 |
||||||
|
Control |
- |
0.70 |
0.17 |
0.58 |
0.74 |
0.79 |
|
Acetylshikonin |
2 × 6 |
6.11 |
0.92 |
5.54 |
6.05*** |
6.26 |
|
1 × 6 |
2.56 |
0.36 |
2.34 |
2.47*** |
2.77 |
|
|
0.5 × 6 |
1.41 |
0.32 |
1.14 |
1.29** |
1.77 |
|
|
Caspase-3 |
||||||
|
Control |
- |
12746 |
3155 |
10359 |
12019 |
13714 |
|
Acetylshikonin |
2 × 6 |
31618 |
3155 |
29396 |
31226*** |
33530 |
|
1 × 6 |
22653 |
4647 |
18898 |
21756*** |
25119 |
|
|
0.5 × 6 |
13582 |
3737 |
10009 |
13186 |
17705 |
|
|
|
||||||
|
** P < 0.01, *** P < 0.001, vs. control |
||||||
|
Xiong et al. Chinese Medicine 2009 4:14 doi:10.1186/1749-8546-4-14 |
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