Table 5

Bioactivities of synthetic analogues of andrographolide

Name

Bioactivities

References

Derivatives of 12-hydroxy-14-dehydroandrographolide

↓ TNF-α and IL-6 secretion in mouse macrophages

[13]

3,19-O-diacetylanhydroandrographolide

↓ NF-κB-dependent trans-activation in the RAW264.7 cells

[17]

DRF3188

block MCF-7 cell cycle at the G0/G1 phase

↑ cell cycle inhibitor, p27

↓ the levels of CDK4

[46]

14-Alphal-lipoyl andrographolide

↑ against H9N2, H5N1 and H1N1 viruses to reduced the death rate, prolonged life and inhibited lung consolidation and viral titers

[83]

14-Glycinyl andrographolide hydrochloride

↓ reduced virulence factor production

[84]

SRJ23

↑ G1 arrest and apoptosis in MCF-7 and HCT-116

[62]

SRJ09

↑ G1 arrest and apoptosis in MCF-7 and HCT-116

[62]

3,19-isopropylideneandrographolide

↑cyotoxicity against MCF-7 and HCT-116

[47]

14-acetyl-3,19-isopropylidene andrographolide

↑cyotoxicity against MCF-7 and HCT-116

[47]

Chao and Lin Chinese Medicine 2010 5:17   doi:10.1186/1749-8546-5-17