Table 1 |
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|
In vitro anti-RSV activity of compounds I-IV (n = 3) |
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|
Compound |
CC50(μM) a |
IC50 (μM) b |
SI |
|
|
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|
I |
29.9 (3.2) |
- |
- |
|
II |
106.1 (5.9) |
9.6 (0.7) |
11.0 |
|
III |
145.3 (3.1) |
6.6 (1.1) |
21.9 |
|
IV |
161.5 (5.7) |
10.2 (0.8) |
15.8 |
|
Ribavirin |
256.1 (3.2) |
11.9 (0.2) |
21.6 |
|
|
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|
a CC50 is the concentration of sample with half maximal inhibition on the growth and survival of HEp-2 cells; data are expressed as mean (SD). b IC50 is the concentration that reduced 50% of CPE in respect to virus control; data are expressed as mean (SD). -: The sample did not show anti-RSV effect at its NMCC. |
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|
Huang et al. Chinese Medicine 2010 5:23 doi:10.1186/1749-8546-5-23 |
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