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Open Access Highly Accessed Review

Bioactivities of major constituents isolated from Angelica sinensis (Danggui)

Wen-Wan Chao and Bi-Fong Lin*

Author Affiliations

Department of Biochemical Science and Technology, College of Life Science, National Taiwan University, Taipei 10617, Taiwan

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Chinese Medicine 2011, 6:29  doi:10.1186/1749-8546-6-29

Published: 19 August 2011

Abstract

Danggui, also known as Angelica sinensis (Oliv.) Diels (Apiaceae), has been used in Chinese medicine to treat menstrual disorders. Over 70 compounds have been isolated and identified from Danggui. The main chemical constituents of Angelica roots include ferulic acid, Z-ligustilide, butylidenephthalide and various polysaccharides. Among these compounds, ferulic acid exhibits many bioactivities especially anti-inflammatory and immunostimulatory effects; Z-ligustilide exerts anti-inflammatory, anti-cancer, neuroprotective and anti-hepatotoxic effects; n-butylidenephthalide exerts anti-inflammatory, anti-cancer and anti-cardiovascular effects.