Anti-inflammatory effects of Radix Gentianae Macrophyllae (Qinjiao), Rhizoma Coptidis (Huanglian) and Citri Unshiu Pericarpium (Wenzhou migan) in animal models.
Kim KS, Rhee HI, Park EK, Jung K, Jeon HJ, Kim JH, Yoo H, Han CK, Cho YB, Ryu CJ, Yang HI, Yoo MC.
East-West Bone and Joint Research Center, Kyung Hee University Neo Medical Hospital, 149 Sangil-dong, Gangdong-gu, Seoul 134-090, South Korea. labrea46@yahoo.co.kr.
ABSTRACT: BACKGROUND: KHU14, an ethanolic extract of Radix Gentianae Macrophyllae (Qinjiao), Rhizoma Coptidis (Huanglian) and Citri Unshiu Pericarpium (Wenzhou migan) was tested for its anti-inflammatory effects. METHODS: Three out of 20 herbs were found to have anti-inflammatory effects. The formulation of these herbs, i.e. KHU14 was tested for croton oil-induced ear edema, carrageenan-induced paw edema, acetic acid-induced capillary permeability, cotton pellet and delayed type hypersensitivity. RESULTS: KHU14 exhibited anti-inflammatory effects in animal models of acute and chronic inflammation. The anti-inflammatory activity of KHU14 observed was comparable to that of celecoxib. KHU14 inhibited the production of NO and PGE2 in LPS/IFN-gamma-stimulated peritoneal macrophages, and reduced edema and the amount of infiltrated cells in animal models. CONCLUSION: KHU14 exhibited anti-inflammatory effects as demonstrated in typical immunological tests for anti-inflammation in vitro and in vivo.
PMID: 18761750 [PubMed - in process]PMCID: PMC2546402